A new review this month has agreed with a report in January that mRNA vaccines, particularly those from Pfizer, may have the potential of causing neurodegenerative diseases.

In January, a report authored by J. Bart Classen, MD. was published in the ‘Microbiology and Infectious Diseases’ journal, which the title that reads ‘COVID-19 RNA Based Vaccines and the Risk of Prion Disease.” Classen suggested the push for an immediate vaccine to cope with the pandemic has made specialists forgo deeper studies on the long-term effects the vaccines may induce. 

“RNA based vaccines offer special risks of inducing specific adverse events,” said the report. “One such potential adverse event is prion based diseases caused by activation of intrinsic proteins to form prions.”

The Pfizer vaccine employs the mRNA technology, which uses mimic fragments of the genetic material of the Chinese Communist Party (CCP) Virus, but not the actual virus itself, which triggers the immune system into action.

Classen’s paper claims that the RNA sequence in the vaccine can cause TDP-43 and FUS (two of the human proteins) to abnormally change the way they fold, which consequently leads to “the development of common neurodegenerative diseases.”

Prion disease is caused by the abnormal arrangement of one’s proteins, which causes them to aggregate. These amyloid aggregates can then damage cells, resulting in neurological disorders. Nationalfile noted that TDP-43 could cause dementia, ALS, and even Alzheimer’s, whereas FUS, is linked to ALS and Hereditary Essential Tremors. 

Although the paper did not include any experimental evidence that the two proteins will bind with the mRNA molecules from the vaccine, Classen’s experiment provided the conclusion the possibility was there. Hence, the report wrapped up with a warning that the “approval of the RNA based vaccines for SARS-CoV-2 was premature,” which could make the effort to ward off the CCP-Virus creates “a bioweapon and even more dangerous than the original infection.”

A recent review was published on Monday, May 10, co-authored by Stephanie Seneff, who works at the Computer Science and Artificial Intelligence Laboratory at MIT, and Dr. Greg Nigh, a specialist in Naturopathic Oncology at Immersion Health in Portland, Oregon expanding on Classen’s findings.

The researchers provided that the RNA fragments from the distributed vaccines could be different from those used in clinical trials and carry more risk. The latter was produced via a much more tightly controlled manufacturing process.

“These fragments, if translated by the cell following injection, would generate incomplete spike proteins, again resulting in altered and unpredictable three-dimensional structure and a physiological impact that is at best neutral and at worst detrimental to cellular functioning,” the review stated. 

The researchers also quoted The European Medicines Agency saying that no adequate data was proving that the RNA fragments will not lead to expressed proteins. 

“These [fragmented RNA] forms are poorly characterized, and the limited data provided for protein expression do not fully address the uncertainties relating to the risk of translating proteins/peptides other than the intended spike protein” (EMA 2020),” the paper conveyed. “To our knowledge, no data has been forthcoming since that time.”

The researchers noted that they backed the notion that the non-spike proteins generated from fragmented RNA “would at least contribute to the cellular stress that promotes prion-associated conformational changes in the spike protein that is present.” Still, the idea of them being susceptible to misfolding and capable of causing neurodegenerative diseases was not what they claimed.